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Remember this is a PEPTIDE (messenger), not a trans-dermal filler

Tan L, He R, Zheng X

in addition to its crucial role in maintaining genomic stability and regulating inflammation, SIRT6 also directly deacetylates NAMPT, enhancing its activity and promoting NAD + synthesis via the salvage pathway

however, clinical trials in humans are very limited

In our study, most dermatologists prefer oral Glutathione, with IV use much less common due to safety concerns. This preference reflects the medical communitys risk-benefit assessment, where the potential for serious adverse events with injectable forms outweighs uncertain cosmetic benefits